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In a subsequent study in young beagle dogs, oral ciprofloxacin doses of 30 mg/kg and 90 mg/kg ciprofloxacin (approximately 1.3-times and 3.5-times the pediatric dose based upon comparative plasma AUCs) given daily for 2 weeks caused articular changes which were still observed by histopathology after a treatment-free period of 5 months

It also tends to cause long-term heart diseases and increase the chances of heart stroke

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In 2009, Lucky Strike Silver (the brand marketed as lighter) changed their UK packs from the quintessential red design to blue, albeit with a red teaser outer covering the packet